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KMID : 0367419780190090036
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Journal of Korean Pediatric Society
1978 Volume.19 No. 9 p.36 ~ p.43
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The Effect and Complication of Longterm Use of Corticosteroid in Children
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李承珠/Lee, Seung Joo
權惠淑/吳義淑/孫權贊/Kwon, Hae Sook/Oh, Esook/Sohn, Keun Chan
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Abstract
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Since the demonstration of Corticosteroid in 1949, there has been very widespread employment with optimism due to its dramatic effect in many patients suffering from nephrotic syndrome and rheumatoid arthritis, etc. But with increasing experiences of this regimen, serious side effects have been noted with longterm use.
The effects and various side effects were observed in 92 patients of childhood nephrotic syndrome and juvenile rheumatoid arthritis who had longterm treatment for longer than two month.
The treatment was withdrawn due to complete remission in 23 patients, unsatisfactory response in 18 patients and death in 3 patients. In the remaining patients, steroid treatment was continued for several months to several years with favorable response.
Undesirable side effects and complications observed throughout this study were hypertention infection, growth retardation, mental disturbance, gastrointestinal trouble including peptic ulcer, osteoporosis, in order.
From this study, it is considered that the treatment should be employed only on very restricted indications for its risk of considerable complication, and recently alternate day ther apy was recommended due to its less side effects.
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